The importance of identifying ALK rearrangements^1,2

**Signaling pathways mediated by ALK rearrangements**^1,2

The NSCLC treatment landscape has rapidly evolved since the discovery of ALK rearrangement as a potential oncogenic driver for tumor cell growth and replication.^1,2

Multiple signaling pathways are implicated in mediating the oncogenic effects of deregulated ALK activity.²

These ALK-mediated pathways are known regulators of cell cycle progression, proliferation and apoptosis, and their dysregulation is a common feature of NSCLC.²

Identification of signaling networks mediated by ALK rearrangements is critical to our understanding of ALK-driven tumorigenesis and the development of targeted therapies.²

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ALK: anaplastic lymphoma kinase; NSCLC: non-small-cell lung cancer.

Siddiqui F, Siddiqui AH. Cancer, Lung. [Updated 2020 Apr 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482357/?report=classic. Accessed August 2020.
Golding B, et al. The function and therapeutic targeting of anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC). Molecular Cancer 2018:17:52.

The importance of identifying ALK rearrangements1,2

Signaling pathways mediated by ALK rearrangements1,2

Identification of signaling networks mediated by ALK rearrangements is critical to our understanding of ALK-driven tumorigenesis and the development of targeted therapies.2

LEARN ABOUT TESTING GUIDELINES

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The importance of identifying ALK rearrangements^1,2

**Signaling pathways mediated by ALK rearrangements**^1,2

Identification of signaling networks mediated by ALK rearrangements is critical to our understanding of ALK-driven tumorigenesis and the development of targeted therapies.²

^{LEARN ABOUT TESTING GUIDELINES}